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...Microscopyresearchandtechnique combiningopticaltweezersandscanningprobe microscopytostudydna proteininteractions jurgenh g huisstede vinodsubramaniam andmartinl bennink biophysicalengineeringgroupandmesa institutefornanotechnology facultyofscienceandtechnology university of twente ae enschede the netherlands keywords optical tweezers scanning probe microscopy dnaprotein interactions dig oxygenin single molecule force spectroscopy abstract wepresenttherst results obtained with a new instrument designed and built to study at level this microscope combines allows us locate dna binding proteins on suspended is stretched taut using while scanned along interaction forces between sample are measured thus enables correlate mechanical andfunctional properties bound tension within typical friction micropipette used as naked was found be pn thenetherlands e mail m l utwente nlorv subramaniam nl in many ot afm experi receivedapril acceptedjuly ments change elastic doi jemt result protein studied p...