Introduction to DOX • An experiment is a test or a series of tests • Experiments are used widely in the engineering world – Process characterization & optimization – Evaluation of material properties – Product design & development – Component & system tolerance determination • “All experiments are designed experiments, some are poorly designed, some are well-designed” Chapter 1 Design & ...
Chapter 7 Design & Analysis of Experiments 2 8E 2012 Montgomery Blocking a Replicated Design • This is the same scenario discussed previously in Chapter 5 • If there are n replicates of the design, then each replicate is a block • Each replicate is run in one of the blocks (time periods, batches of raw material, etc.) • Runs within the block ...
Experiments with Blocking Factors • Blocking and nuisance factors • The randomized complete block design or the RCBD • Extension of the ANOVA to the RCBD • Other blocking scenariosLatin square designs Chapter 4 Design & Analysis of Experiments 2 7E 2009 Montgomery The Blocking Principle • Blocking is a technique for dealing with nuisance factors • A nuisance factor is a factor ...
Scale-up Approach with Dimensional Numbers • The effect of process parameter (i.e., impeller speed, liquid addition rate) on the process and thus on granule characteristics are evaluated based on mechanistic understanding. • Use dimensional numbers as variables rather than individual process parameters. This will decrease the number of variables need to be varied, thus the number of experiments ( includes explicitly includes liquid addition ...
Idealised Experimental Design: Fisher Analyse Data to Reach Conclusions Make an Observation “Pre-milked tea was not “Tea tastes better when detectable above chance ” you add the milk first” Formulate a Hypothesis Design an Experiment and Collect Data “A seasoned tea drinker “Present a random should be able to selection of prepared teas determine a superior tea at to the expert ...
Materials design and optimization A major goal of the Materials Genome Initiative and “Materials-by- Design” is the acceleration of materials property optimization. 2 Learning properties of a material Another important problem is to learn the underlying Kinetic pathways of controlled release physics of a new material or system Materials specific physical parameters Dominant processes during fabrication or reactions to Compositional Ripening external stimuli. Optimization ...
What to do: 1) Connect the experimental plan / study design to the study question(s) / aims 2) Justify your choice of study design. Why is your study the best way to address your study question? 3) Use correct study design terminology. Observational, cohort, case-control, pilot, prospective, retrospective, matched, etc Clinical trial ? (parallel, cross-over, factorial, randomized, blinded, controlled, etc) 4) Justify your sample size ...
Types of centrifugation • Based on purpose • ANALYTICAL & PREPARATIVE • Analytical- measuring the physical properties of the sedimenting particles such as sedimentation coefficient or molecular weight • Preparative- Isolate specific particles which can be reused Analytical Ultracentrifugation – Applications • determine sample purity • characterize assembly and disassembly mechanisms of biomolecular complexes • detect and characterize macromolecular confirmational changes • measure equilibrium ...
Sequence alignment • A way of arranging two or more sequences to identify regions of similarity • Shows locations of similarities and differences between the sequences • An 'optimal' alignment exhibits the most similarities and the least differences • The aligned residues correspond to original residue in their common ancestor • Insertions and deletions are represented by gaps in the alignment • Examples Protein ...
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