Section 2 Tablet Processing By Dr. Cecil W. Propst Table of Contents Tablet Processing........................................................................................................................1 Table of Contents....................................................................................................................1 Process Objective...................................................................................................................2 Content Uniformity..............................................................................................................2 Material Composition..........................................................................................................2 Wet Granulation.......................................................................................................................5 Advantages of Wet Granulation..........................................................................................6 Disadvantages of Wet Granulation......................................................................................7 Dry Mixing...........................................................................................................................7 Wet Mixing...........................................................................................................................7 Ingredients fir Wet Granulation............................................................................................8 Binders..........................................................................................................................10 Avicel® PH Microcrystalline Cellulose (MCC) in Wet Granulation.................................10 Wet Milling.........................................................................................................................11 Drying of Granules ............................................................................................................11 Drying of Milling ................................................................................................................14 Direct Compression...............................................................................................................14 Advantage of Direct ...
IJRPC 2017, 7(3), 232-238 Sandip Joshi et al. ISSN: 22312781 INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Research Article Available online at www.ijrpc.com TO STUDY AND UNDERSTAND THE PROCESS OF WET GRANULATION BY FLUIDIZED BED GRANULATION TECHNIQUE * Sandip Joshi and Rohan Kamat Pravara College of Pharmacy, Ahmednagar, Loni Bk, Maharashtra-413 736, India. ABSTRACT Fluidized bed granulation is a widely used wet granulation technique in the pharmaceutical industry to produce solid oral dosage forms. The process involves ...
Wet granulation of milled lactose MCC Starch Lactose Inhalation Superdisintegrants Summary Lactose is commonly wet granulated with microcrystalline cellulose in the preparation of pharmaceutical tablets. The studies reported in this article examine the effects of lactose / MCC ratio, lactose particle size and polyvinylpyrrolidone concentration on granule and tablet properties. It was found that the breaking force of tablets made by high shear granulation of lactose and MCC is most affected by the lactose / MCC ratio and the particle ...
Universidade de Lisboa Faculdade de Farmacia Modelling a fluidized wet granulation process Miguel Guerreiro Barata Mestrado Integrado em Ciencias Farmaceuticas 2020 1 2 Universidade de Lisboa Faculdade de Farmacia Modelling a fluidized wet granulation process Miguel Guerreiro Barata Monografia de Mestrado Integrado em Ciencias Farmaceuticas apresentada a Universidade de Lisboa atraves da Faculdade de Farmacia Orientador: Professor Auxiliar, Doutor Joao Pedro Martins de Almeida Lopes 2020 3 4 ...
Acta Poloniae Pharmaceutica n Drug Research, Vol. 68 No. 5 pp. 725n733, 2011 ISSN 0001-6837 Polish Pharmaceutical Society ANALYSIS OF WET GRANULATION PROCESS WITH PLACKETT-BURMAN DESIGN n CASE STUDY KRZYSZTOF WOYNA-ORLEWICZ and RENATA JACHOWICZ* Department of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University, Faculty of Pharmacy, 9 Medyczna St., 30-688 KrakUw, Poland Abstract: According to Process Analytical Technology perspective, drug product quality should be ensured by manufacturing process design. Initial step of the process analysis is investigation of critical process parameters ...
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