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...Serial vs direct layout page liquid handling dilution time to apply new thinking ic determination and dose response analysis by dr john comley the method is standard practice in preparation of series for however it well recognised that inadequacies or mixing technique will affect ratio hence compound concentration any errors be compounded during each successive mix transfer a recent poll end users ranked better precision particularly at lower drug concentrations reduction precipitation as improvements they most desired addition now suspected hydrophobic compounds may lost from solution aqueous dilutions absorbed intermediate plastic surfaces this turn adds concern over reliability results generated extent which are true reflection potency being evaluated part general drive enhance quality screening data researchers investigating strategies based on micro volumes ie volumetric basis these investigations have been aided availability low volume dispensing systems with good nl dispense rel...