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picture1_Simulation Ppt 78225 | Mannino Heiberger Fedorov


picture2_Simulation Ppt 78225 | Mannino Heiberger Fedorov picture3_Simulation Ppt 78225 | Mannino Heiberger Fedorov

 67x       Filetype PPTX       File size 0.31 MB       Source: www.r-project.org


File: Simulation Ppt 78225 | Mannino Heiberger Fedorov
Outline • Motivation for using modeling & simulation in designing late-stage clinical trials • Simulation approach used at GSK • Example using RExcel interface • Conclusions Issues in Multicenter ...

icon picture PPTX Filetype Power Point PPTX | Posted on 04 Sep 2022 | 2 years ago

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...Outline motivation for using modeling simulation in designing late stage clinical trials approach used at gsk example rexcel interface conclusions issues multicenter are costly and inefficient simplistic assumptions lead to underpowered trial variability not properly accounted drug supply process can be very wasteful independent design decisions made about interacting factors patient recruitment how many centers long will we wait etc randomization statistical patients best analysis model dropouts use of simulations emphasizing only a single factor sometimes permit analytic results e g finding sample size dealing with multiple or abnormal characteristics cannot handled analytically allow us handle interactions r package toolkit mstpackage developed within research statistics unit has been approximately different studies typical run take between hours depending on complexity number scenarios being considered...
								

							

						
	
												
				
					
					
					
			
					
				
				
		
	

	
		





	

	
				

						

						
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										Category:  Uncategorized / Uncategorized 
										
Posted on: 04 Sep 2022 | 2 years ago
										
										
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Filetype: PPTX
										
File size: 0.31 MB
										
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