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...Iscience ll openaccess review anintegrative approach to dietary balance across the life course davidraubenheimer alistair m senior christen mirth zhenweicui ronghou davidg lecouteur samantha solon biet pierre leopold and stephen j simpson summary animals require specic blends of nutrients that vary with circumstances e g health activity levels underpinning compli cating these requirements is individual traits may be optimized on different compositions leading nutrition mediated trade offs among outcomes additionally food environment constrain which nutrient mixtures are achievable natural selection has equipped for solving such multi dimen sional dynamic challenges but little understood about details andtheirtheoreticalandpracticalimplications wepresentanintegrativeframe work nutritionalgeometry whichmodelscomplexnutritionalinteractionsinthe context multiple biological organization cellular population analysis mechanistic theuniversity sydney developmental ecological evolutionary frame...