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...Acta scientific pharmaceutical sciences issn volume issue april review article new method development by hplc and validation as per ich guidelines arunadevi shantappa birajdar received march professor k t patil college of pharmacy osmanabad maharashtra india published corresponding author all rights are reserved abstract this paper consists the information it also explains importance types columns in binger clearly understand how carried out what regarding any first step we have to check solubility apis same solvent find absorption range lambda max then dilution api absorbance linearity curve for both compounds single well mixture applied on formulations its application explained detail parameters such selectivity accuracy precision lod loq ruggedness robustness stability system suitability s std values will help budding students keywords introduction normal phase mode stationary is polar most drugs multicomponent dosage forms can be ana mobile nonpolar nature technique lyzed because s...