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...Literature study oceana biomedicina journal vol no jan jun extended spectrum beta lactamase esbl verna biutifasari lecturer of department clinical pathology faculty medicine hang tuah university surabaya east java indonesia email address vernaisjwara gmail com abstract antibiotics have been widely used today use is also often in mass and not accordance with the indication among others a particular case fish poisoning on beach treatment given without clearly are excessive can cause resistance to these one lactam antibiotic that works inhibits cell walls inappropriate lead occur at various levels resistances broad an enzyme has ability hydrolyze penicillin type first generation cephalosporins two three as well monobactam groups throughout produced by many enterobactericeae especially escherichia coli klebsiella pneumoniae enterobacteriaceae patterns caused resistant inhibitors tem derivatives cephalosporinase be difficult detect because differentiatedactivity detected microbiology phenot...