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...Experimental design basic principles formulate question goal in advance comparison control replication randomization stratification aka blocking factorial experiments example does salted drinking water affect blood pressure bp mice experiment provide a mouse with containing nacl wait days measure good are comparative compare fed salt to plain strain b ideally the group is compared concurrent controls rather than historical why replicate reduce effect of uncontrolled variation i e increase precision quantify uncertainty related point an estimate no value without some statement subjects units should be assigned treatment groups at random not mean haphazardly one needs explicitly randomize using computer or coins dice cards avoid bias for first six you grab may have intrinsically higher role chance allows later use probability theory and so gives solid foundation statistical analysis...