File: The Role Of P90 Ribosomal S6 Kinases (rsks) In Steroid Signalling Ryan Cronin
the role of p90 ribosomal s6 kinases rsks in steroid signalling ryan cronin a thesis submitted for the title of master of science by dissertation school of biological sciences university ...
Filetype PDF | Posted on 14 Jan 2023 | 2 years ago
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...The role of p ribosomal s kinases rsks in steroid signalling ryan cronin a thesis submitted for title master science by dissertation school biological sciences university essex examination march abstract are family serine threonine consisting four isoforms rsk which regulate key cellular processes including cell cycle proliferation motility and survival among several transcription factors targeted studies have identified receptors srs as substrates subfamily nuclear receptor superfamily five proteins androgen glucocorticoid estrogen progesterone mineralocorticoid these gene expression thus involved crucial organ development maintenance immune system neuroprotection metabolic homeostasis importantly main drivers hormone driven cancers therefore we hypothesised that could play an important part sr within cancer progression this was investigated using recombinant dna techniques to incorporate genes into mammalian vector pcdna produce phospho mimetic mutants luciferase assays were used det...