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...The journal of nutrition and disease total parenteral induces liver steatosis apoptosis in neonatal piglets huiwang vladimiri khaoustov buvaneswarikrishnan wei cai barbara stoll douglas g burrin boris yoffe departmentofmedicine michaele debakeyveteransaffairsmedicalcenter baylorcollegeofmedicine houston tx department pediatrics u s agriculture ars children research center molecular virology microbiology baylor college medicine downloaded from https academic oup com jn article by guest on january abstract tpn a high rate infants yet pathogenesis remains elusive we usedneonatalpigletsasananimalmodeltoassessearlyeventsleadingtotpn mediatedliverinjury newbornpiglets n were nourished for d or enteral en tissue isolated hepatocytes subjected to morphologic analysis histological revealed prominent grade pigs whereas minimal was observed only abundant cytosolic cytochrome c dna fragmentation compared with markers mitochondrial fas mediatedapoptosiswerealteredintpnlivertissue asindicatedbyalowe...