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...Scientia chromatographica instituto internacional de cromatografia sample preparation http dx doi org sc issn techniques for biological samples maria eugenia costa queiroz israel donizeti souza abstract departamento quimica facul it is essential to determine drugs and their metabolites or biomarmarkers in dade filosofia ciencias e letras g serum plasma breast milk cerebrospinal fluid urine ribeirao preto universidade sao quantitatively clinical studies including therapeutic drug monitoring metabolism investigation diagnostic prognostic purposes because paulo sp brazil are extremely complex matrices direct injection of into conventional chromatographic systems not convenient a c step usually necessary eliminate the majority endogenous compounds av bandeirantes cep concentrate analytes that often exist at traces levels this context brasil review presents an overview how our research group has contributed mariaeqn ffclrp usp br development innovative microextraction methods solid phase te...