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...The european agency for evaluation of medicinal products emea mrl committee veterinary papaverine summary report dimethoxy isoquinoline hydrochloride is an alkaloid isolated from opium which possesses a smooth muscle relaxant activity with particularly marked action on blood vessels especially in brain administered by parenteral administration im iv treatment and prevention immediate or delayed anoxia newborn calf only target animal species at dose level to mg kg b w acts inhibiting phosphodiesterase responsible breakdown cyclic amp increase concentration cells causes fall free intercellular calcium contractile protein sensitivity ensuring relaxation fibres after oral therapeutic man dog rat bioavailability approximately plasma peak obtained within hour this dogs intravenous infusion over period one was found high levels liver fatty tissues absorbed bioconverted two hours o demethylation give phenolic compounds these are eliminated glycurono sulpho conjugation inactivation detoxication...