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...Chapter complex formation thorsteinn loftsson mspharm phd and marcus e brewster bonding stability metal ion coordination complexes cyclodextrins molecular in pharmacy chemistry chemical processes the word usually between small substrates a large ligand such as refers to molecules or assemblies formed by com drug protein g plasma binding bination of s ligands l most often plexes some is reversible process polyalcohol also m n clude dimers pairs intramolecular interactions base dna helix clath where substrate associate with rate compounds cage like lattice form stoichiometry this context one type hydroquinone molecule entraps plex complexation association che second methanol pharma lation are synonymous kept ceutical co crystals can be considered together relatively strong coordinate covalent bonds components subjected hydrogen weak non forces van der other crystal examples these types waals electrostatic dipole charge include isoniazid aminosalicylic transfer release conformational stra...