bp302t physical pharmaceutics i theory unit iv complexation and protein binding introduction complexation is the process of complex formation that is the process of characterization the covalent or non covalent ...
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...Bpt physical pharmaceutics i theory unit iv complexation and protein binding introduction is the process of complex formation that characterization covalent or non interactions between two more compounds ligand a molecule interacts with another drug to form molecules can complexes other small macromolecules such as proteins coordination product lewis acid base reaction in which neutral anions called ligands bond central metal atom ion by coordinate bonds simple include water ammonia chloride ions once occurs chemical properties complexing species altered are solubility stability partition co efficient energy absorption emission conductance forces involved ordinate van der waals force dispersion dipole interaction hydrogen beneficial effects therefore lead enhanced aqueous e g theophylline ethylenediamine aminophylline inclusion labile drugs cyclodextrins also aid optimization delivery systems exchange resins affect distribution body after systemic administration result some instances p...