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...British journal of dermatology supplement pharmaceutical formulations anthralin m whitefield dermal laboratories limited hitchin herts downloaded from https academic oup com bjd article s by guest on january apart the essential aspect stability there are three other principal factors which affect formulation a drug for dermatological use must be released its it partition into outer layers skin permeate through epidermis therapeutic action can occur only if reaches receptor sites in sufficient quantities is important therefore to ensure that base does not interact with thereby impeding release e g complexing due hydrogen bonding contrary should have much greater physico chemical affinity substrate than formulated addition particles minimum particle size provide maxi mum surface area reactivity and optimal biological effectiveness best system molecular dispersion true solution however this advantage outweighed an solvent molecules solute so most efficient will pro vided employing poorly ...