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...Calorie restriction and nad sirtuin counteract the hallmarks of aging shaday michan instituto nacional de geriatria institutos nacionales salud d f mexico table contents abstract introduction effect cr in normal cognition neuroprotection counteracts cellular genome instability is reduced by telomere erosion decreased epigenetic alterations are counteracted proteostasis imbalance modified mitochondrial dysfunction relieved senescence reversed stem cells depletion attenuated impaired nutrient sensing reprogramed altered intercellular communication improved pathway effects mediated activating compounds mimic concluding remarks acknowledgement references among diverse environmental factors that it has been nearly eighty years since clive m modify diet a profound mccay first demonstrated decrease energy intake which entails consumption without increased lifespan white rats then malnutrition only natural regimen shown to extend large body experiments confirmed maximum mean as well healthspan...