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...Research highlights www nature com clinicalpractice endmet the analysis included data from osteo treatment with hpth nasal spray porotic men who had received either alen increased patients lumbar bmd in a dose dronate mg daily teriparatide g dependent manner after months at month or both for serum levels of bone turnover markers by compared baseline interestingly n telopeptide osteocalcin and amino while increase was around terminal propeptide type procollagen half that reported injec were regularly assessed alendronate tions level group marker initially declined formation elicited then remained stable only about fifth seen all three during injections this discrepancy could have arisen first decreased because unlike towards over next also suppressed resorption combination authors conclude higher than those mono is safe transient hypercalcemia therapy but much lower observed efficacious monotherapy osteoporosis its long term effects note setting warrant investigation slightly original a...