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picture1_Study Pdf 10652 | Chemotherapy | Ilmu Kesehatan


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File: Study Pdf 10652 | Chemotherapy | Ilmu Kesehatan
cancer chemotherapy cytotoxic drugs hormones antihormones and biologic agents have become increasingly effective means of treating cancer many patients are treated on protocols to provide optimal therapy for refractory or ...

icon picture PDF Filetype PDF | Diposting 01 Jul 2022 | 4 thn lalu
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...Cancer chemotherapy cytotoxic drugs hormones antihormones and biologic agents have become increasingly effective means of treating many patients are treated on protocols to provide optimal therapy for refractory or poorly responsive malignancies treatment may be inadequate ineffective because drug resistance the tumor cells this has been attributed spontaneous genetic mutations in subpopulations prior exposure after eliminated sensitive resistant subpopulation grows predominant cell type goldie coldman hypothesis basis alternating non cross regimens molecular mechanisms now subject intense study instances specific results from an amplification number gene copies enzyme inhibited by a chemotherapeutic agent more general form multidrug mdr described association with expression encoding transmembrane glycoprotein mw p protein is energy dependent transport pump that facilitates efflux promotes broad spectrum unrelated acquired multiple myeloma lymphoma reversed clinically adding calcium ch...

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